Ovine Placental Lactogen (oPL) Lacks Anabolic Action in the Postnatal Lamb
نویسندگان
چکیده
منابع مشابه
Binding inhibition by monoclonal antibodies of ovine placental lactogen to growth hormone receptors in human liver.
In the radioreceptor assay for growth hormone (RRA-GH) using [125I]iodo-hGH, hGH and human liver membrane particulate fractions as tracer, hormone standard and receptors, respectively, ovine placental lactogen (oPL) is capable of inhibiting the binding of [125I]iodo-hGH in a parallel manner with hGH and in equipotency. Similarly, in the RRA-GH by employing [125I]iodo-oPL, oPL and human liver me...
متن کاملDevelopment of the sheep as an animal model to study placental lactogen physiology.
Ovine placental lactogen, purified from term sheep cotyledons, has been found to have chemical and biologic properties similar to those of human placental lactogen, ovine growth hormone, and ovine prolactin. OPL stimulates lactation in vivo and in vitro and binds to prolactin and growth hormone membrane receptors. Its binding to growth hormone receptors is approximately 20 times greater than th...
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A prospective study has been carried out of placental lactogen levels in pregnancy complicated by diabetes mellitus. The levels were higher than those in normal pregnant subjects; the higher levels were related to increased placental and fetal weight but more closely to the former; and lower levels were found when there was clinical evidence of placental dysfunction. Those patients requiring th...
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The somatogenic and galactopoietic effects of recombinant ovine placental lactogen (oPL) were compared with the effects of recombinant ovine growth hormone (oGH) in post-weaned growing lambs and in lactating ewes. In two experiments that each lasted 35 days, 2-month-old lambs were given daily subcutaneous injections (0.1 mg/kg live weight) of oPL or oGH, and their daily growth rates were compar...
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Although parathyroid hormone (PTH) has long been known to act as a bone anabolic agent when administered intermittently, the exact underlying mechanisms remain largely unknown. Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, has been identified to be a PTH target gene in vitro and in vivo. Here, we used female global AREG knockout (AREG-KO) mice to explore the role of ARE...
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ژورنال
عنوان ژورنال: Clinical Pediatric Endocrinology
سال: 1994
ISSN: 0918-5739,1347-7358
DOI: 10.1297/cpe.3.supple5_181